Certain $2 bills can be highly valuable, selling for hundreds or even thousands of dollars at auction, depending on their condition, rarity, and unique serial numbers. Collectors particularly seek notes from 2003 and earlier, with some fetching as much as $4,500.Certain $2 bills can be highly valuable, selling for hundreds or even thousands of dollars at auction, depending on their condition, rarity, and unique serial numbers. Collectors particularly seek notes from 2003 and earlier, with some fetching as much as $4,500.