Certain foods and drinks can wreak havoc on an empty stomach, potentially leading to digestive discomfort. High-acid foods like citrus fruits and coffee can exacerbate acid reflux, while sugary drinks and treats can cause blood sugar spikes. Spicy and greasy foods can also irritate an empty stomach, leading to indigestion and discomfort.Certain foods and drinks can wreak havoc on an empty stomach, potentially leading to digestive discomfort. High-acid foods like citrus fruits and coffee can exacerbate acid reflux, while sugary drinks and treats can cause blood sugar spikes. Spicy and greasy foods can also irritate an empty stomach, leading to indigestion and discomfort.